Police say it was a Hope Hull man behind the wheel of a sport utility vehicle that collided into a Greyhound bus early Friday on Interstate 65.
Captain Huey Thornton, a police spokesman, said 45-year-old Joseph Rudder was driving northbound in the southbound lane of the highway when he crashed head-on into the bus.
Rudder was transported to a Montgomery hospital, where he died a short time later.
The wreck happened at about 2:16 a.m. Thornton said shortly before the collision, officers were dispatched to I-65 to search for a driver who was traveling on the wrong side of the interstate.
36 of the 52 bus passengers along with the bus driver, 36-year-old Cedric Davis of Stone Mountain, Georgia, were treated for an array of injuries. None were life threatening. One person remains hospitalized.
The crash forced the closure of both sides of the interstate and the roadway was reopened about four hours later.