It happened around 9:30 a.m. in the area of Cecil Ashburn Drive near Carl T. Jones Drive, near the Blevins Gap Nature Preserve.
Police said an eastbound Buick LeSabre crossed the center line and hit a westbound Honda minivan.
The crash caused the Buick to catch fire and pushed the Honda on the driver's side against a guardrail.
Witnesses at the scene pulled the driver out of the Buick.
The driver of the Buick was David Shotts, 35. Monday afternoon, hospital officials said Shotts was listed in fair condition.
There were four people in the minivan; the driver was trapped inside, but the other passengers were able to climb out.
Firefighters reported that when they pulled the driver from the vehicle, they lost her vital signs. She was identified as Martha Radzinski, 66. The passengers were Phillip Radzinski, 65, Leigh Allyson Bridenstine, 39, and Scott A. Bridenstine, 42.
Radzinski was taken to Huntsville Hospital, where she later died. The four other people involved were also taken to the hospital, one of whom is in serious condition. Phillip Radzinski is listed in good condition.
A woman who works in that area said she knows how treacherous that stretch of road can be.
"We see the ambulances and a bunch of fire trucks always going this way," said Aubrey Dunn. "We also have customers who complain about turning left into here because of all the traffic."
Cecil Ashburn Drive was closed for about two hours between Bailey Cove to Old Cove while crews worked to clear the scene.Police are still investigating the wreck.
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